Detailed Information

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Basic Information

The table below details the source and basic information of this item.

Title Content
iBAD ID iBAD_0000062
Karyotype Trisomy 21
Type RNA-Seq
Diseases Down syndrome
Organism Homo sapiens
Tissue Blood
Cell Line Circulating endothelial progenitor cells
Platform GPL9442
Accession GSE27443
GEO Title RNA-Seq of rRNA depleted circulating endothelial progenitor cells (cEPCs) in trisomy 21 and euploid samples
PMID 21533138
Article Title Massive-scale RNA-Seq analysis of non ribosomal transcriptome in human trisomy 21
Author Costa V, Angelini C, D'Apice L, Mutarelli M, Casamassimi A, Sommese L, Gallo MA, Aprile M, Esposito R, Leone L, Donizetti A, Crispi S, Rienzo M, Sarubbi B, Calabrò R, Picardi M, Salvatore P, Infante T, De Berardinis P, Napoli C, Ciccodicola A
GEO Link https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27443
Pub Link https://www.ncbi.nlm.nih.gov/pubmed/21533138
FTP Download ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE27nnn/GSE27443/
SRA Run Selector -
SRP -

Differentially Expressed Genes

The gene expression matrix, up- and down-regulated gene list are provided. Click the three following options to download the corresponding list.

GO enrichment

The result of Gene Ontology (GO) enrichment analysis from up- (goup) or down-regulated (godown) genes is shown as follows. Select the option that you’d like to display. The result that failed to enrich wouldn’t be displayed.

KEGG Enrichment

The result of KEGG enrichment analysis from up- (goup) or down-regulated (godown) genes is shown as follows. Select the option that you’d like to display. The result that failed to enrich wouldn’t be displayed.

Interaction network

The network analysis was performed by STRING with up- and down- regulated genes. Select the option that you’d like to display. The different cluster was colored with different colors.

Genome Browser

You can browse the expression pattern of this item as follows, or click “Full-screen view” to display the patterns of all items stored in BDdb. By this, you are allowed to compare different groups observed by different sequencing approaches.

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