Detailed Information

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Basic Information

The table below details the source and basic information of this item.

Title Content
iBAD ID iBAD_0000055
Karyotype Trisomy 21
Type DNA methylation
Diseases Down syndrome
Organism Homo sapiens
Tissue Connective
Cell Line Fibroblasts
Platform GPL11154
Accession GSE55505
GEO Title Domains of genomewide gene expression dysregulation in Down syndrome [RRBS]
PMID 24740065
Article Title Domains of genome-wide gene expression dysregulation in Down's syndrome
Author Letourneau A, Santoni FA, Bonilla X, Sailani MR, Gonzalez D, Kind J, Chevalier C, Thurman R, Sandstrom RS, Hibaoui Y, Garieri M, Popadin K, FalcoNonet E, Gagnebin M, Gehrig C, Vannier A, Guipponi M, Farinelli L, Robyr D, Migliavacca E, Borel C, Deutsch S, Feki A, Stamatoyannopoulos JA, Herault Y, van Steensel B, Guigo R, Antonarakis SE
GEO Link https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE55505
Pub Link https://www.ncbi.nlm.nih.gov/pubmed/24740065
FTP Download ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE55nnn/GSE55505/
SRA Run Selector https://www.ncbi.nlm.nih.gov/Traces/study/?acc=PRJNA239813
SRP SRP039350

Bed Download

The methylation information with BED format was performed by Bismark and was provided here. Click the options to download the corresponding list.

Differential Methylation

The differential methylation was produced by methylKit, an R package. There would be no result if the experiment design cannot meet the requirement of methylKit.

Chromosome Start End Strand P-value Meth.diff
"chr1" 632001 633000 "*" 6.0373075555297e-20 -36.4227642276423
"chr1" 775001 776000 "*" 1.34379554756352e-07 -35.8058608058608
"chr1" 778001 779000 "*" 7.98913511858522e-33 25.374935452729
"chr1" 823001 824000 "*" 1.8762657754989e-12 30.0915854215346
"chr1" 832001 833000 "*" 4.31368698025385e-13 28.2594452937323
"chr1" 906001 907000 "*" 8.11898741999964e-54 -37.9757267006293
"chr1" 911001 912000 "*" 6.15771169771392e-09 -41.0714285714286
"chr1" 918001 919000 "*" 1.21034088050896e-30 31.9127459122018
"chr1" 919001 920000 "*" 4.7587948848486e-10 -35.6467532467532
"chr1" 944001 945000 "*" 3.60313542523235e-38 -28.210573089753
"chr1" 958001 959000 "*" 1.13252816372537e-295 -74.7134433180945
"chr1" 961001 962000 "*" 2.50705738599804e-224 -35.3319127895253
"chr1" 981001 982000 "*" 8.25620485044962e-07 25.7630064081677
"chr1" 992001 993000 "*" 0.001109319684182 28.4523809523809
"chr1" 993001 994000 "*" 1.56407583723594e-08 61.5615615615616
"chr1" 995001 996000 "*" 3.695186848106e-59 39.995895541532
"chr1" 996001 997000 "*" 8.74765873155688e-29 40.2692039916454
"chr1" 1014001 1015000 "*" 8.12453949561734e-11 -50
"chr1" 1034001 1035000 "*" 0 -30.1993414023262
"chr1" 1038001 1039000 "*" 1.92615163690927e-08 -26.4036023225501
"chr1" 1063001 1064000 "*" 1.38010350364421e-34 31.9212188777406
"chr1" 1075001 1076000 "*" 1.90651600665353e-27 -28.5991585545441
"chr1" 1076001 1077000 "*" 9.03780091029272e-11 -26.9463157163692
"chr1" 1077001 1078000 "*" 2.99020775253191e-21 27.1863089173176
"chr1" 1110001 1111000 "*" 4.57397095444794e-50 -57.4123989218329
"chr1" 1117001 1118000 "*" 8.19884958790055e-14 54.0894220283533
"chr1" 1160001 1161000 "*" 4.53793103678496e-22 46.7734902986701
"chr1" 1162001 1163000 "*" 1.01810609272586e-85 -29.1529369627507
"chr1" 1164001 1165000 "*" 5.88406703817478e-152 25.8947713427981
"chr1" 1165001 1166000 "*" 4.1283858452526e-53 25.1833759414456
"chr1" 1212001 1213000 "*" 2.14980439793763e-68 33.7467958163509
"chr1" 1330001 1331000 "*" 9.82106003058485e-07 66.6666666666667
"chr1" 1341001 1342000 "*" 1.46029329084581e-05 50
"chr1" 1342001 1343000 "*" 0.000249756705661166 -26.096256684492
"chr1" 1345001 1346000 "*" 7.08641723527848e-15 29.1476250542815
"chr1" 1425001 1426000 "*" 3.38666693659969e-11 -34.524870743448
"chr1" 1438001 1439000 "*" 8.37226673396829e-18 26.3529863193917
"chr1" 1463001 1464000 "*" 7.24363345623527e-08 -31.8260120585702
"chr1" 1465001 1466000 "*" 7.92227710751159e-54 34.1507413044704
"chr1" 1468001 1469000 "*" 1.89625215629836e-30 -35.2846648301194
"chr1" 1472001 1473000 "*" 2.01034223359992e-182 -43.0346591692778
"chr1" 1510001 1511000 "*" 1.58017071313454e-57 29.5729478231971
"chr1" 1514001 1515000 "*" 1.26804385281201e-07 -29.9435028248588
"chr1" 1578001 1579000 "*" 5.40050410428852e-08 32.4906367041199
"chr1" 1596001 1597000 "*" 3.98075451781922e-09 91.1764705882353
"chr1" 1603001 1604000 "*" 1.99160594634696e-16 25.0629190777992
"chr1" 1604001 1605000 "*" 3.06389958202416e-14 40.1663695781343
"chr1" 1656001 1657000 "*" 3.0565541600298e-06 -25.1693404634581
"chr1" 1658001 1659000 "*" 2.06185870585503e-38 -25.5931746744499
"chr1" 1748001 1749000 "*" 4.74339698422268e-23 47.4978204010462
"chr1" 1782001 1783000 "*" 9.82376536696378e-224 -57.7333773225077
"chr1" 1888001 1889000 "*" 1.83564271042892e-57 30.6651349444137
"chr1" 1896001 1897000 "*" 3.99856655175976e-10 30.44357469015
"chr1" 1912001 1913000 "*" 1.04504605270597e-05 28.1338481338481
"chr1" 1916001 1917000 "*" 0.000280170221157381 -43.2129173508484
"chr1" 1921001 1922000 "*" 8.12910982613131e-23 -32.026875699888
"chr1" 1922001 1923000 "*" 2.2832354774061e-13 -25.2345796618242
"chr1" 1925001 1926000 "*" 1.02368502760477e-10 29.2371553884712
"chr1" 1963001 1964000 "*" 1.56313970850691e-05 39.5833333333333
"chr1" 1969001 1970000 "*" 1.8599743310751e-23 33.4980279061877
"chr1" 1984001 1985000 "*" 5.7240191449698e-06 29.7767497988737
"chr1" 1987001 1988000 "*" 6.79066074315756e-15 -69.5730247406225
"chr1" 1988001 1989000 "*" 5.25632958739058e-07 27.4582425562818
"chr1" 1989001 1990000 "*" 2.9299217953938e-39 58.4197246448357
"chr1" 2008001 2009000 "*" 2.10717524265846e-17 -33.5714394042798
"chr1" 2023001 2024000 "*" 2.82312662464112e-30 27.5182923297703
"chr1" 2032001 2033000 "*" 3.05495177101568e-25 -38.4738382819611
"chr1" 2038001 2039000 "*" 3.16936377014745e-05 31.2566122017162
"chr1" 2040001 2041000 "*" 8.67027245519797e-20 32.582962160427
"chr1" 2077001 2078000 "*" 5.20079114572792e-06 -42.8571428571429
"chr1" 2085001 2086000 "*" 0.00241170144010736 36
"chr1" 2104001 2105000 "*" 3.43474571935073e-09 35.6315614064323
"chr1" 2125001 2126000 "*" 1.48372206457594e-36 -32.8937267653985
"chr1" 2162001 2163000 "*" 9.06605809329913e-10 64.7058823529412
"chr1" 2164001 2165000 "*" 1.48185241076405e-22 47.3597359735974
"chr1" 2195001 2196000 "*" 7.68765493852834e-28 47.2972972972973
"chr1" 2197001 2198000 "*" 4.20302473183091e-17 37.3576430455648
"chr1" 2206001 2207000 "*" 1.46429268057021e-35 -27.3968844043194
"chr1" 2209001 2210000 "*" 9.0559001276193e-31 99.3670886075949
"chr1" 2239001 2240000 "*" 3.51746413660866e-28 -25.359911406423
"chr1" 2240001 2241000 "*" 4.2615584392289e-12 -51.4195583596215
"chr1" 2255001 2256000 "*" 2.28207129521531e-38 52.0268391044361
"chr1" 2290001 2291000 "*" 1.24470708746844e-05 -27.0444638186574
"chr1" 2301001 2302000 "*" 8.48461565679569e-69 -32.6035092863474
"chr1" 2313001 2314000 "*" 3.68896835935383e-21 28.6005106617901
"chr1" 2339001 2340000 "*" 4.76758529284929e-21 -26.7643954760818
"chr1" 2359001 2360000 "*" 5.35123044003064e-19 28.2754358574031
"chr1" 2361001 2362000 "*" 7.73859411633616e-14 -26.5368447738139
"chr1" 2377001 2378000 "*" 1.14371025407075e-17 36.5655339805825
"chr1" 2406001 2407000 "*" 3.4668199707445e-52 -30.9955285489172
"chr1" 2429001 2430000 "*" 7.97145585432491e-05 -29.2452830188679
"chr1" 2448001 2449000 "*" 6.8648708672369e-61 30.4647634391344
"chr1" 2463001 2464000 "*" 1.24982669587526e-48 41.199609638916
"chr1" 2480001 2481000 "*" 0.00545280155964554 -32.1985815602837
"chr1" 2485001 2486000 "*" 8.32569528854312e-30 58.8935574229692
"chr1" 2486001 2487000 "*" 4.67971387758103e-07 26.7526925421662
"chr1" 2494001 2495000 "*" 1.73875540236409e-28 37.5716674440224
"chr1" 2548001 2549000 "*" 1.12251037515619e-52 -25.3066685230074
"chr1" 2550001 2551000 "*" 8.96048648755376e-10 27.0899502164183
"chr1" 2563001 2564000 "*" 5.50434924727e-37 26.205306973443
"chr1" 2576001 2577000 "*" 1.20553185160497e-53 26.807494294358
"chr1" 2578001 2579000 "*" 1.10800724416227e-07 -38.8049450549451
"chr1" 2603001 2604000 "*" 5.13616124896334e-34 37.5095650847855
"chr1" 2609001 2610000 "*" 6.05594617524367e-16 36.036238394729
"chr1" 2622001 2623000 "*" 3.25373181045071e-11 -59.5652173913043
"chr1" 2623001 2624000 "*" 5.99453688535727e-07 -26.1538461538461
"chr1" 2644001 2645000 "*" 6.93118300768394e-44 32.9341506173774
"chr1" 2656001 2657000 "*" 1.23056323894615e-09 75
"chr1" 2659001 2660000 "*" 0.00814061377562757 29.2758620689655
"chr1" 2672001 2673000 "*" 2.64055712260617e-07 43.695652173913
"chr1" 2683001 2684000 "*" 1.7712022133556e-08 42.6666666666667
"chr1" 2827001 2828000 "*" 4.04399927310194e-09 -38.0952380952381
"chr1" 2841001 2842000 "*" 0.00168871376301717 -66.6666666666667
"chr1" 2872001 2873000 "*" 5.96361939349627e-07 -45.1807228915663
"chr1" 2895001 2896000 "*" 3.04293014535231e-13 61.2903225806452
"chr1" 2903001 2904000 "*" 2.88478819050304e-08 44.6808510638298
"chr1" 2929001 2930000 "*" 6.82549668778666e-05 25.5737704918033
"chr1" 2937001 2938000 "*" 5.32530205966651e-11 -25.2955082742317
"chr1" 2941001 2942000 "*" 5.00694801710301e-08 54.7619047619048
"chr1" 2950001 2951000 "*" 0.00721492933635369 -29.185520361991
"chr1" 2951001 2952000 "*" 0.00133745579467827 -33.3333333333333
"chr1" 2961001 2962000 "*" 1.21399873421226e-15 39.7966594045025
"chr1" 2972001 2973000 "*" 1.55838221659395e-08 25.7696238104362
"chr1" 2980001 2981000 "*" 3.42684367519851e-06 28.8594900245386
"chr1" 3003001 3004000 "*" 4.07409384412134e-15 -27.8480281468256
"chr1" 3017001 3018000 "*" 1.64953431346161e-13 36.6470496444415
"chr1" 3096001 3097000 "*" 8.48034069993033e-10 32.1428571428571
"chr1" 3109001 3110000 "*" 4.01073318448361e-26 25.7404680085092
"chr1" 3115001 3116000 "*" 2.97336419937655e-76 61.005863424723
"chr1" 3125001 3126000 "*" 2.63432975290148e-22 29.1244876237063
"chr1" 3128001 3129000 "*" 1.1430497907731e-26 27.0241000013048
"chr1" 3129001 3130000 "*" 3.96413166520487e-07 -25.1741293532338
"chr1" 3131001 3132000 "*" 9.03787879292211e-19 48.3006535947712
"chr1" 3137001 3138000 "*" 3.17334367984753e-21 43.2017055988135
"chr1" 3145001 3146000 "*" 8.48588819908759e-17 61.5384615384615
"chr1" 3154001 3155000 "*" 2.32907787427618e-19 76.4044943820225
"chr1" 3183001 3184000 "*" 1.38216411616626e-73 32.5915852975587
"chr1" 3190001 3191000 "*" 7.28531665865732e-10 35.2180672612716
"chr1" 3201001 3202000 "*" 7.8772782912811e-14 43.947082276187
"chr1" 3213001 3214000 "*" 1.13488553619174e-31 28.5176720227265
"chr1" 3218001 3219000 "*" 3.01805053868415e-15 -37.3470856320461
"chr1" 3242001 3243000 "*" 3.03318731576814e-19 -37.366452991453
"chr1" 3247001 3248000 "*" 1.81787618040228e-94 32.4962198645444
"chr1" 3251001 3252000 "*" 2.13872008287511e-09 73.0769230769231
"chr1" 3252001 3253000 "*" 8.82181713275989e-51 28.6583243429314
"chr1" 3259001 3260000 "*" 3.4010512914229e-24 -38.6219098760238
"chr1" 3260001 3261000 "*" 1.05310565522117e-10 -40.983893557423
"chr1" 3262001 3263000 "*" 0.000347314097406736 -46.3777089783282
"chr1" 3283001 3284000 "*" 5.77702441924216e-118 34.9351023346704
"chr1" 3294001 3295000 "*" 1.37869199418562e-19 -30.8458273906842
"chr1" 3296001 3297000 "*" 8.25515955591712e-16 -28.4918391591613
"chr1" 3314001 3315000 "*" 3.17183758776967e-20 39.1497975708502
"chr1" 3315001 3316000 "*" 8.37343624794273e-27 -29.5460826240564
"chr1" 3322001 3323000 "*" 8.25545205747577e-41 28.5818106312292
"chr1" 3335001 3336000 "*" 8.17496003064067e-17 26.4042995839112
"chr1" 3339001 3340000 "*" 8.26701526872557e-07 25.473137973138
"chr1" 3352001 3353000 "*" 1.70389245792711e-33 26.8190619621343
"chr1" 3385001 3386000 "*" 2.92756400385958e-14 26.2701801012186
"chr1" 3391001 3392000 "*" 9.86051312789522e-80 27.7607919506654
"chr1" 3399001 3400000 "*" 0.00010197770761887 -27.0588235294118
"chr1" 3410001 3411000 "*" 3.15181412083853e-37 26.9816889900851
"chr1" 3417001 3418000 "*" 1.19784456259038e-24 25.5778697296141
"chr1" 3427001 3428000 "*" 2.10078171769141e-10 37.3795435333897
"chr1" 3438001 3439000 "*" 2.85379732858227e-05 -50
"chr1" 3491001 3492000 "*" 4.23495150457642e-11 -55.8375634517767
"chr1" 3510001 3511000 "*" 1.90165341283782e-22 88.4297520661157
"chr1" 3511001 3512000 "*" 2.15319750906122e-06 40.5087014725569
"chr1" 3523001 3524000 "*" 7.41050014651828e-41 -40.4036436413969
"chr1" 3532001 3533000 "*" 4.30226193303588e-18 -42.5474254742547
"chr1" 3541001 3542000 "*" 4.40719704438631e-21 -28.5460992907801
"chr1" 3555001 3556000 "*" 2.75607769175498e-33 27.9284720343241
"chr1" 3577001 3578000 "*" 8.82319354767088e-05 -34.4754653130287
"chr1" 3586001 3587000 "*" 7.1825618492702e-08 27.0737767584098
"chr1" 3587001 3588000 "*" 1.96110210399291e-08 -29.0441767068273
"chr1" 3598001 3599000 "*" 3.38012112587954e-61 28.3247706539511
"chr1" 3599001 3600000 "*" 5.72898056339754e-33 36.9302616536163
"chr1" 3605001 3606000 "*" 3.63299275100635e-08 82.803738317757
"chr1" 3612001 3613000 "*" 3.73388845904011e-08 -44.6428571428571
"chr1" 3615001 3616000 "*" 9.01364457679366e-30 63.1922603582661
"chr1" 3631001 3632000 "*" 6.09808342728508e-07 -34.7222222222222
"chr1" 3653001 3654000 "*" 3.91693819923825e-13 38.8260254596888
"chr1" 3674001 3675000 "*" 1.15430343799285e-12 29.9647887323944
"chr1" 3679001 3680000 "*" 7.05538853383924e-20 26.9681600450831
"chr1" 3696001 3697000 "*" 1.25852210628452e-43 -40.7542981817265
"chr1" 3699001 3700000 "*" 3.69016527468273e-30 34.5810283305793
"chr1" 3702001 3703000 "*" 8.02442411728342e-13 30.4493464052288
"chr1" 3715001 3716000 "*" 5.04278862128651e-20 45.9642659346481
"chr1" 3774001 3775000 "*" 7.45739829743508e-50 28.5096588782568
"chr1" 3793001 3794000 "*" 2.08558763337942e-06 -41.8803418803419
"chr1" 3820001 3821000 "*" 0.000130657890395105 -62
"chr1" 3832001 3833000 "*" 0.00684706637412875 33.6607142857143
"chr1" 3852001 3853000 "*" 1.30340942244799e-12 -39.9122807017544
"chr1" 3890001 3891000 "*" 4.12837483688334e-12 28.4090909090909
"chr1" 3907001 3908000 "*" 2.02244654190742e-14 41.036036036036
"chr1" 3909001 3910000 "*" 7.76044531925952e-17 27.415599262733
"chr1" 3911001 3912000 "*" 1.42362432543845e-39 25.253517137192
"chr1" 3930001 3931000 "*" 2.98341884145805e-27 60.99466606566
"chr1" 3945001 3946000 "*" 1.202454336249e-36 37.0255106513544
"chr1" 3955001 3956000 "*" 8.0560395856756e-50 28.5029101169939
"chr1" 3979001 3980000 "*" 1.68081066742119e-06 28.4615384615385
"chr1" 3981001 3982000 "*" 4.25716488952396e-24 -43.3816844367303
"chr1" 3995001 3996000 "*" 5.3931287903556e-37 58.7131837307153
"chr1" 4027001 4028000 "*" 3.85693286637427e-107 49.1771652498305
"chr1" 4057001 4058000 "*" 3.10222754971056e-07 28.2512626262626
"chr1" 4060001 4061000 "*" 5.55562708525674e-09 28.5714285714286
"chr1" 4091001 4092000 "*" 0.00145270384899067 52.5396825396825
"chr1" 4124001 4125000 "*" 1.25584224446402e-10 43.298969072165
"chr1" 4129001 4130000 "*" 3.93858971557157e-19 -29.8944439898535
"chr1" 4138001 4139000 "*" 7.40231438164446e-08 25.7615546218487
"chr1" 4161001 4162000 "*" 1.44175603870563e-39 -27.377243988702
"chr1" 4171001 4172000 "*" 4.80987141254643e-270 -57.4802499743089
"chr1" 4172001 4173000 "*" 3.11015578470555e-12 -42.5283173361234
"chr1" 4175001 4176000 "*" 4.08329855045259e-05 -41.6666666666667
"chr1" 4217001 4218000 "*" 8.49183964840719e-17 -32.6852596764101
"chr1" 4233001 4234000 "*" 3.16240404560741e-07 39.7697540554683
"chr1" 4367001 4368000 "*" 1.46741513617825e-10 -28
"chr1" 4470001 4471000 "*" 0.0115190479129973 -26.9230769230769
"chr1" 4499001 4500000 "*" 5.46673098468683e-11 -50.6925207756233
"chr1" 4504001 4505000 "*" 2.8351421540276e-06 100
"chr1" 4505001 4506000 "*" 2.90287149327821e-22 26.0119570951292
"chr1" 4511001 4512000 "*" 2.73586039863943e-13 -56.4619883040936
"chr1" 4512001 4513000 "*" 6.2020112243197e-14 100
"chr1" 4527001 4528000 "*" 6.84455093938882e-19 -56.1476969927674
"chr1" 4595001 4596000 "*" 1.53930888087035e-13 -50.3571428571429
"chr1" 4603001 4604000 "*" 0.000586236959985569 -50
"chr1" 4627001 4628000 "*" 1.08583321031807e-12 25.7275871004638
"chr1" 4631001 4632000 "*" 2.84335396231465e-06 29.5681063122924
"chr1" 4653001 4654000 "*" 8.10904025282568e-61 -30.9412299478192
"chr1" 4675001 4676000 "*" 7.69790346773749e-08 -30.7692307692308
"chr1" 4696001 4697000 "*" 2.71243803809479e-15 -31.9019253270929
"chr1" 4700001 4701000 "*" 1.71274289937201e-25 -35.9289272514405
"chr1" 4705001 4706000 "*" 0.00409202060004525 -33.3333333333333
"chr1" 4714001 4715000 "*" 2.46746220490359e-11 31.0074341823331
"chr1" 4719001 4720000 "*" 7.69922396622543e-10 -27.5862068965517
"chr1" 4734001 4735000 "*" 2.9898907812672e-57 25.9185013950567
"chr1" 4735001 4736000 "*" 8.27221322303118e-25 26.9817850637523
"chr1" 4779001 4780000 "*" 8.01252129578752e-09 25.3151544662663
"chr1" 4940001 4941000 "*" 2.36983863850396e-12 76.9230769230769
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"chr1" 33499001 33500000 "*" 6.18650864468228e-11 82
"chr1" 33520001 33521000 "*" 3.56779549643416e-13 -32.2920139054241
"chr1" 33798001 33799000 "*" 0.00111718529797355 51.8614718614719
"chr1" 34030001 34031000 "*" 1.18814285503262e-12 -34.061135371179

Genome Browser

You can browse the expression pattern of this item as follows, or click “Full-screen view” to display the patterns of all items stored in BDdb. By this, you are allowed to compare different groups observed by different sequencing approaches.

ShenZhen, Guangdong province, China